Adrafinil is an agent that may promote alertness and wakefulness. ✝Download COA

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Adrafinil Specification

CAS ID 63547-13-7
Chemical Name 2-[(Diphenylmethyl)sulfinyl]-N-hydroxyacetamide
Synonyms Adrafinil, CRL 40028
Molecular Formula C15H15NO3S
Molar Mass 289.349 g/mol
Storage Room Temperature

Adrafinil Chemical Structure

Adrafinil Capsules

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ThoughtFoods supplies Adrafinil in bottles of 60 and sachets of 6 capsules. Each capsules contains 300mg of high purity Adrafinil. Every ThoughtFoods Adrafinil batch is being independently and in house lab tested. When you buy Adrafinil capsules from ThoughtFoods before 3pm, you can be sure it will be shipped same day.

Adrafinil Reviews

The reviews available here are the opinions of contributors who may or may have not used these products, and do not necessarily represent the views of ThoughtFoods. These reviews represent one’s opinion and should not be taken as fact or recommendation. ThoughtFoods makes no warranty to the accuracy of information provided by these reviews. Read legal disclaimer

Adrafinil Dosage

The recommended daily dosage is between 150-300 mg. New users should start with the lowest dose and get used to it first before taking higher doses. Currently, there is very little to suggest that dosages higher than 300 mg per day will have more benefits as it is a potent nootropic compound. Due to its anti-sleep effects, Adrafinil should not be taken in the evening. However, if you accidently take Adrafinil late in the evening, it will not stop a good night’s sleep. Interestingly, evidence suggest that Adrafinil does not negatively affect a the quantity or quality of nocturnal sleep (i.e., normal sleep pattern). Adrafinil should not be taken more than three times a week, for longer than five months. Therefore, Adrafinil should be used on a non-continuous basis by taking it in cycles. Take Adrafinil strategically during the times when you need a great cognitive performance booster.

Compared to Modafinil, it takes slightly longer for Adrafinil and its effective metabolites to reach active levels in the bloodstream. Specifically, if taken on an empty stomach it takes around 45-60 minutes for Adrafinil capsules to start working. It has a half-life of around 5 hours.

Adrafinil Benefits

Adrafinil may help with the following:

  • Increased alertness
  • Better mental focus
  • Higher energy levels
  • Increased motivation
  • Vigilance enhancement
  • Stimulates mental function
  • Feeling less lethargic
  • Reduced mental fatigue
  • Reduced daytime sleepiness

Adrafinil Side Effects

There are little to no side effects associated with Adrafinil if used at recommended dosages. Very few individuals may experience mild headaches or nausea.

How Adrafinil Works?

The exact mechanism of action of Adrafinil is not yet fully understood. However, it is known that Adrafinil is converted to modafinil in the liver. With regards to specific mechanisms of action, a few hypotheses have been proposed.

Firstly, it has been suggested that Adrafinil is a central alpha 1-adrenergic agonist that acts on α-adrenergic receptors in the CNS. A stimulation of these receptors by Adrafinil increases alertness and wakefulness. The same receptors are stimulated by the adrenaline and noradrenaline. Secondly, Adrafinil may increase the brain metabolic rate by regulating energy substrates and various important neurotransmitters.2 Finally, Adrafinil may also play a role in the regulation of excitatory and inhibitory (i.e., GABA) amino acid neurotransmitters.2

What is Adrafinil?

Adrafinil is a synthetic nootropic that is chemically very similar to Modafinil. In fact, Adrafinil works by increasing the levels of Modafinil in the body. Therefore, pharmacological effects of these two compounds are pretty much identical. Adrafinil was originally developed by a French pharmaceutical company and until 2011 marketed under the brand name of Olmifon. Adrafinil is a cognitive-enhancing therapeutic (CET) compound designed to relieve excessive daytime sleepiness and inattention in elderly patients. Modafinil (bioactive metabolite of Adrafinil) is an effective wakefulness promoting agent used by people with other disorders, such as Parkinson’s disease, multiple sclerosis, depression and obstructive sleep apnoea. Due to its effects, Adrafinil is often used to treat narcolepsy, sleep and attention disorders and is well-known for its ability to promote alertness and wakefulness. That is why Adrafinil is classified as an eugeroic (“the good arousal”) agent.

For example, Adrafinil is widely used by night shift workers who suffer from the Shift Work Sleep Disorder (SWSD) as it increases their overall productivity by improving cognitive performance, wakefulness and mood during the night shift. Most importantly, Adrafinil use does not result in the addictive potential and development of tolerance often associated with more traditional stimulants. Lack of undesirable effects has helped Adrafinil gain popularity as a very effective caffeine replacement. It is used by a wide range of people, including busy businessmen and soldiers.

Adrafinil has stimulant properties but is a unique wakefulness promoting agent as, unlike other stimulants that target the whole Central Nervous System (CNS), it only stimulates the circadian ‘clock’ of the brain. Further, it specifically targets the chemical processes within the brain thereby improving mental focus. Interestingly, it does so without affecting heart rate or blood pressure. This prevents side effects that are often associated with more common central nervous system stimulants (e.g. caffeine).

Although, Adrafinil is mainly used as a nootropic agent to improve alertness some other cognitive and physical benefits have been reported. Some users experience improvements in memory and learning capacity following its use. In addition, there are studies in the elderly showing its clinical efficiency as a mood-enhancing agent. Experimental animal models also demonstrate increases in activity following Adrafinil administration. Following improvements in psychometric tests and motor function in patients with mild cognitive impairments, it has been proposed by scientists to use Adrafinil in the treatment of age-associated memory impairment. It is important to note that Adrafinil does not have any anxiolytic effects.

Overall, Adrafinil is an effective agent to boost mental energy and increase alertness. This makes it a perfect compound to increase your productivity only when absolutely necessary as prolonged use of Adrafinil is not recommended.


  1.     Mignot, E.J.M. 2012. A practical guide to the theraphy of narcolepsy and hypersomnia syndromes. Neurotherapeutics, 9, 739-752.
  2.     Milgram, N.W., Callahan, H. & Siwak, C. 1999. Adrafinil: a novel vigilance promoting agent. CNS Drug Reviews, 5 (3), 193-212.
  3.     Moreno, J.D. 2006. Juicing the brain. Scientific American Mind, 17(6), 66-73.
  4.     Scamell, T.E. et al. 2000. Hypothalamic arousal regions are activated during Modafinil-induced wakefulness. The Journal of Neuroscience, 20 (22), 8620-8628.
  5.     Schwartz, J.R.L. & Roth, T. 2008. Neurophysiology of sleep and wakefulness: basic science and clinical implications. Current Neuropharmacology, 6, 367-378.
  6.     Szabadi, E. 2006. Drugs for sleep disorders: mechanisms and therapeutic prospects. British Journal of Clinical Pharmacology, 61 (6), 761-766.
  7.     Walsh, J.K., Randzzo, A.C., Stone, K.L. & Schweitzer, P.K. 2004. Modafinil improves alertness, vigilance, and executive function during simulated night shifts. Sleep, 27, 434-439.


✝These statements have not been evaluated by the Food and Drug Administration (FDA) The above products are not intended to diagnose, treat, cure or prevent any disease. 

Adrafinil COA

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Adrafinil Capsules Reviews

ThoughtFoods Adrafinil Capsules

4.5(based on 33 reviews)

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By on 23 Oct. 2016
Focus & alert guaranteed
My colleague mentioned Adrafinil as the best nootropic for focus and alert and she didn’t lie! We often work very long hours in the office which requires immense amount of mental energy & concentration so Adrafinil is fantastic for that! Highly recommend for anyone in similar jobs. Will be buying from ThoughtFoods again.
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By on 09 June 2016
i love it!
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By on 29 May 2016
Absolutely fantastic nootropic
I think Adrafinil is the best nootropic for focus, concentration & mental alertness currently available on the market. I’ve been struggling with general fatigue (chronic fatigue syndrome not diagnosed though) for a very long time. Despite my best effort to work hard, stay focused & concentrated, the number of times I’ve been accused of being lazy is incredible. People wouldn’t understand when I told them that I constantly suffer from mental fatigue which prevents me from being as productive as they are. After a while I’ve decided to find a nootropic compound that would help me reduce the effects of mental fatigue and tiredness in my daily life. This is when I came across Adrafinil, which has been absolutely amazing in improving my concentration, focus and mental energy levels. I’m 100% certain I would have continued struggling in my daily and working life without Adrafinil.
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By on 25 May 2016
The dosage says no more than 3 x a week, for up to 5 months. But reviewers are talking about a daily dose. Comments, please? Hi, It’s recommended to take Adrafinil as and when required with occasional days off. For example, you could take Adrafinil on working days and give yourself a ‘rest’ on weekends. Some users may take Adrafinil on a continuous basis for medical reasons.
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By on 20 May 2016
I wish all freebies were as good
Adrafinil is simply awesome, which is even better when you get it as a free sample! Thanks guys!
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By on 21 March 2016
(Too) strong
For me 300mg was too strong. Doing a second dose in the afternoon lead to a massive crash with headaches and slight symptoms of a panic attack. Had a walk outside to calm me down. 150mg was just fine.
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By on 15 March 2016
Probably the best nootropic i've tried - lots of pluse and no minuses detected so far. Pulls all the higher functions together. My mindI feels 20+ years younger !
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By on 13 March 2016
Increases mental sharpness
1 capsule a day is definitely enough for me to feel Adrafinil’s powerful effects. I take it with breakfast before the start of my working day and it keeps me alert throughout the day. I feel mentally sharp, which helps me to complete my tasks more efficiently without being distracted. More efficient at work equals more time to do other things that I enjoy.
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By on 10 March 2016
Never been so alert!
Purchased Adrafinil during the preparation period for my exams as I was desperate for an extra boost during those 2 long weeks. It worked immediately and I have never been so alert before! As any typical student I had a few all-nighters and Adrafinil got me through them, I honestly couldn’t have done it without taking Adrafinil. I felt really vigilant which obviously helped me to take all the information in. Service was top class too! Great stuff indeed!
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