Tianeptine Sulfate

Tianeptine Sulfate, a Non-sedating anxiolytic compound ✝

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Sachet of 6 tabs x 30mg Bottle of 120 tabs x 30mg



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What is Tianeptine Sulfate?

Tianeptine is an atypical antidepressant, originally developed by the French company Servier in the early 1980s. Compared to more common antidepressant agents that are selective serotonin reuptake inhibitors (SSRIs), Tianeptine works as a selective serotonin reuptake enhancer (SSRE). Up until recently, the monoamine hypothesis was the main theoretical framework used to explain depression and anxiety disorders. Specifically, it is known that serotonin, dopamine and norepinephrine are three main neurotransmitters directly involved in the regulation of motivation and mood. For example, deficiencies in serotonin neurotransmitter are associated with depression and anxiety symptoms. Therefore, the monoamine hypothesis suggests that such imbalances and reductions in certain important neurotransmitters can be restored by reversing monoamine deficits. As a result, the SSRIs work by increasing the levels of serotonin neurotransmitter. In contrast, Tianeptine appears to decrease serotonin levels, which made researchers and clinicians revisit the main theory. One of the biggest disadvantages of using traditional SSRIs is their long list of side effects. However, the same cannot be said about Tianeptine, as it has a much better side effect profile. Although, more research is required, Tianeptine may prove to be a safer and more effective pharmacological treatment of depression and anxiety disorders.  

Studies have successfully used Tianeptine in the treatment of depression, anxiety, obsessive-compulsive type behaviours, stress-related disorders and even autistic symptoms. In terms of its nootropic effects (i.e., cognitive functions enhancement), users report improvements in memory, learning abilities and thought clarity following the use of Tianeptine.In addition, Tianeptine has been shown to have neuroprotective properties.

Key benefits:

  • Reduced anxiety
  • Improved mood
  • Alleviate depression
  • Ability to relax
  • Lower social anxiety
  • Neuroprotection

Recommended dosage:

The recommended daily dosage of Tianeptine is 12.5-30 mg, taken once per day. You should not exceed the recommended dosage.

Mechanisms of action:

Despite three decades of studies and research, Tianeptine’s mechanisms of action are not fully understood. However, its neuroprotective properties are linked with the ability to prevent pathological changes and glutamate toxicity in the amygdala and hippocampus areas of the brain. Some evidence suggests that Tianeptine can stop and reverse neural damage.

Side effects:

When used within the recommended dosage, Tianeptine is considered to be safe. However, some of the reported side effects include: drowsiness, dry mouth, dizziness, diarrhea, nausea, headache, constipation, fatigue, joint pain and palpitations. In addition, Tianeptine should not be used by pregnant or lactating women, anyone with kidney problems and/or taking other similar substances, namely monoamine oxidase inhibitors (MAOIs) and selective serotonin reuptake inhibitors (SSRIs).

Compound facts:

Serving size: 1 tablet

Servings per bottle: 120

Amount per serving: Tianeptine 30 mg

This product is free from: Artificial Flavours, Colours & Preservatives, Lactose, Yeast & Gluten

Suitable for: Vegetarians and Vegans


  • Dietary products should not be used as a substitute for a well-balanced and healthy diet.
  • Store in a cool dry place, out of reach of children.
  • Do not use if you are pregnant or breastfeeding.


✝ These statements have not been evaluated by the Food and Drug Administration (FDA) The above products are not intended to diagnose, treat, cure or prevent any disease. You should consult a physician before taking a new product or a nootropic. This product should not be taken by pregnant or nursing mothers, people suffering from cardiovascular disease or those under 18 years of age.

Any studies cited here are not conclusive and are limited to their closed environment nature; they might not determine ones experience with a nootropic, due to a large number of unaccounted variables falling outside the scope of such studies.

The reviews available here are the opinions of contributors who may or may have not used these products, and do not necessarily represent the views of ThoughtFoods. These reviews represent one’s opinion and should not be taken as fact or recommendation. ThoughtFoods makes no warranty to the accuracy of information provided by these reviews. Read legal disclaimer


  1. Cooper, C.M. et al. 2015. Tianeptine in an experimental medicine model of antidepressant action, J Psychopharmacol. 29 (5), 582-90.
  1. Glombik, K. et al. 2016. The effect of chronic tianeptine administration on the brain mitochondria: direct links with an animal model of depression, Mol Neurobiol. [Epub ahead of print].
  1. Godsil, B.P. et al. 2015. Acute tianeptine treatment selectively modulates neuronal activation in the central nucleus of the amygdala and attenuates fear extinction, Mol Psychiatry. 20 (11), 1420-7.
  1. Frančišković, T. et al. 2011. Tianeptine in the combined treatment of combat related posttraumatic stress disorder, Psychiatr Danub. 23 (3), 257-263.

Tianeptine Sulfate Reviews

ThoughtFoods Tianeptine Sulfate

4(based on 1 reviews)

By on 18 Apr. 2016
Great, safe anxiolytic
Tianeptine has proven to be an effective anxiolytic for me. It is non sedating as stated. It helps with my general and social anxiety without being habit forming or tolerance building. I prefer the sulfate over the sodium due to its milder yet longer lasting properties. As with anything, I would recommend doing your own research and getting other opinions as well, but this has been a helpful supplement for me. ThoughtFoods has also become my 'go to' company for ordering most of my supplements. There are helpful, fast, and their phone app is a great way to stream line things.
(Tianeptine Sulfate)
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