Pyritinol - a Nootropic to enhance neuronal metabolic function.✝
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Pyritinol (aka Pyrithioxine and Encephabol) is a nootropic compound and an analogue to vitamin B6. Structurally, Pyritinol is two vitamin B6 (pyridoxine) molecules bound together. Pyritinol is approved in many European countries for “symptomatic treatment of chronically impaired brain function in dementia syndromes” and “cognitive function disturbances”.1
It has been successfully used in the treatment of cognitive decline (e.g., dementia and Alzheimer’s disease) in the elderly. Significant improvements in cognitive performance markers, including “social behaviour” have been shown in geriatric patients.5
Although more studies are required, a randomised, double-blind crossover design study using 12 healthy male volunteers found that acute use of Pyritinol significantly improved performance in critical flicker fusion test (CFFT).3 CFFT is often used to measure the total information processing capacity.
Therefore, Pyritinol appears to be a good mental performance booster that can increase glucose metabolism in the brain thereby improving focus, concentration and memory function. Pyritinol also has antioxidant properties. Interestingly, Pyritinol is marketed as an anti-hangover pill.
The daily recommended dosage of Pyritinol is between 300 – 600 mg. This should be taken with a meal.
Despite the fact that structurally Pyritinol is similar to vitamin B6, the exact mechanisms of action are not fully known. Interestingly, the activity of these two compounds is actually different as Pyritinol has a different pharmacological profile. However, once ingested Pyritinol immediately crosses the blood-brain barrier (BBB) and increases cholinergic transmission in the central nervous system (CNS).2 Choline is a precursor of the acetylcholine (Ach) neurotransmitter which plays a very important role in processes underlying learning, memory, behaviour and decision making.4 As Pyritinol affects the levels of choline, it belongs to the ‘cholinergic’ nootropics family. Pyritinol is also an effective precursor to dopamine, a neurotransmitter in charge of our mood.
Pyritinol is generally well tolerated, but some side effects have been reported. These include irritability, insomnia, skin rashes and digestive problems. Side effects can be prevented by following the recommended dosage (see above) as well as using Pyritinol on a non-continuous basis. For example, you could take it on a “two week on, one week off” basis. Such schedule should guarantee the longevity of the benefits without leading to the unwanted side effects.
Serving size: 1 capsule
Servings per bottle: 120
Amount per serving: Pyritinol 300 mg
This product is free from: Artificial Flavours, Colours & Preservatives, Lactose, Yeast & Gluten
Suitable for: Vegetarians and Vegans
✝ These statements have not been evaluated by the Food and Drug Administration (FDA) The above products are not intended to diagnose, treat, cure or prevent any disease. You should consult a physician before taking a new product or a nootropic. This product should not be taken by pregnant or nursing mothers, people suffering from cardiovascular disease or those under 18 years of age.
Any studies cited here are not conclusive and are limited to their closed environment nature; they might not determine ones experience with a nootropic, due to a large number of unaccounted variables falling outside the scope of such studies.
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