Piracetam is the most popular racetam nootropic that acts on cognitive functions.✝
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Piracetam (aka Nootropyl and UCB6215) is the original racetam, which was first synthesized by Dr Giurgea and marketed by UCB Pharma more than 40 years ago.1, 6 Due to its proven efficacy piracetam remains the most popular nootropic on the market. However, many other effective racetams (e.g., aniracetam, oxiracetam, pramiracetam, phenylpiracetam, coluracetam and nefiracetam) have been synthesized since its discovery and are also used for their wide-ranging nootropic effects on cognitive functions.
Piracetam is a derivative of the neurotransmitter GABA and has a range of effects on the central nervous system (CNS).1 Specifically, Piracetam has been shown to modulate neurotransmission in cholinergic, serotoninergic and glutamatergic systems, improve neuroplasticity and have neuroprotective properties.6In addition, as a cognitive enhancer piracetam is believed to stimulate neuronal function and improve neuronal resistance to injury.2 In terms of its clinical uses, piracetam is used to treat many neurological disorders, cognitive disorders, vertigo, dyslexia and cortical myoclonus.6Piracetam has been shown to be very effective at preventing age-associated cognitive decline and might be successfully used to treat dementia, Alzheimer’s disease and stroke.3
As a nootropic compound, Piracetam is best-known for its positive effects on memory. Piracetam appears to have memory enhancing properties that have been demonstrated in clinical trials.4 Other reported nootropic effects include accelerated cognitive functions and modestly improved attention and mood.4 Interestingly, Piracetam exerts its physiological effects without causing sedation or stimulation.6
Despite many years of research the precise mechanisms of action are not fully understood yet. However, it is known that Piracetam works as a modulator of AMPA receptors, which is a subtype of glutamate receptor.1 This is associated with increased neuronal impulse flow and therefore improved various cognitive functions. It modulates a range of other excitatory and/or inhibitory processes of neurotransmitters, neuro-hormones and/or post-synaptic signals.4 Some evidence also suggests that piracetam is also a metabolic enhancer as it increases cerebral blood flow and glucose metabolism.2
The recommended daily dosage of Piracetam is between 1 and 3 g. Piracetam is water-soluble, and does not need to be taken with food. However, like with most racetams, Piracetam should be taken with a good source of choline (e.g. Alpha GPC or CDP Choline). If you take Piracetam with a source of choline you can expect a greater improvement in memory as they work synergistically.3 Piracetam is rapidly absorbed with peak plasma concentrations in fasting participants observed approximately 30 minutes following oral administration.6
Piracetam is safe and well-tolerated.3, 6 However, at very high dosages you may experience side effects, such as stomach discomfort, nausea, insomnia, headaches, agitation and irritability. Therefore, you should not exceed the recommended daily dosage.
Serving size: 2 capsules
Servings per bottle: 60
Amount per serving: 1000 mg
Other ingredients: Magnesium Stearate; Silicon Dioxide
This product is free from: Artificial Flavours, Colours & Preservatives, Lactose, Yeast & Gluten
Suitable for: Vegetarians and Vegans
✝ These statements have not been evaluated by the Food and Drug Administration (FDA) The above products are not intended to diagnose, treat, cure or prevent any disease. You should consult a physician before taking a new product or a nootropic. This product should not be taken by pregnant or nursing mothers, people suffering from cardiovascular disease or those under 18 years of age.
Any studies cited here are not conclusive and are limited to their closed environment nature; they might not determine ones experience with a nootropic, due to a large number of unaccounted variables falling outside the scope of such studies.
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